you can find some setup videos on the main site ( here )

as for mouse clicks, yes... keyclone will pass mouse clicks to the other screens. to enable it, you must first go to keyclone/setup/general and set the 'pass-mouse-click hotkey' that will toggle it on an off. when you want to pass the clicks, hit the hotkey... hear the 'up' tone indicating it is on... click... don't move the mouse as it clicks on each screen in the same relative spot (the position is scaled relative to the dimensions of the source and target windows)... when you are done, remember to toggle it off (you'll hear a 'down' tone for off)

personally, i use this most often for setting up macros, selecting flight paths, or working with the quest givers. once in a while i'd use it in combat for things like flame strike or blizzard, you just have to remember to toggle it off.

if you have any questions, please feel free to drop me a note.