This is something I came up with after reading Falkor's Automation of Quests (Including Slaves) . Basically, its a way to left click or right click the environment for things like talking to NPCs or dropping AOEs.

Code:
/script SetBinding(".", "TurnOrAction")
/script SetBinding(",", "CameraOrSelectOrMove")
/script SaveBindings(1)
In this case, "." is assigned to right click and "," is assigned to left click. For those of us who hardware box, what this means is so long as we pre-position our mice, we can talk to an NPC, drop AOEs, mine, skin, pick herbs, click portals, etc without having to jump to an individual mouse per character.

Now, as far as I can tell, this only works for interacting with the environment. It won't accept groups or quests or the like, but we already have macros for most of that. The big advantage here is that if you want to drop 5 Blizzards or Flamestrikes or what have you, you can just by hitting the macro and your binding for left click.