Usually I just ignore the snakes, dps him down and worry about the snakes when he's dead. I stand on the room past him and have my dps/healer stand on the pile of bones after the entrance to the room (where the snake-trash paths) and have my paladin stand near the doorway. That way the adds have to travel a bit before reaching my group and by that time the boss is dead :-)

Edit: This will also get you the achievement (defeat him without getting wrapped)