Octopus (by skarlot) is awesome if you can bear going through the motions to set it up. I drive 2 chars primarily from 1 keyboard/mouse.
I do have the 2nd kbd handy for intense situational healing combos. Hotkey autofollow is setup through shortcut ingame & my Razor Tarantula.

I use regular keys for the Hunter and ALT+ combos for the minnie. Works great.
I move my hand way right on the keyboard ASDF is utter crap. I actually use GYUK coz it gives me quick access to more keys and thumb for the ALT.

Pre-Moria I finished all but a couple of the Book quests 2boxing in groups. The best part of it all is when I mention it in groups most ppl say they didnt even notice i was boxing.

Have:
lvl 60 Hunter and Minstrel (luv it, super combo)
lvl 23 Warden 21 RK