Blizzard increased the minimum system requirements for wotlk. there is more detail now than with BC. so there is more information for your system to handle. My guess is you will need to turn down the detail on your alts. your system is ok. but I think your weakest link is your video cards. Is your main screen being run on one card and the 2 alts screens being run on the other cards? This would be the best set-up. but either way 3 big screen on those video cards is really pushing them, my best guess is the detail increase from wotlk on your already strained video cards is too much for them to handle. i think wotlk is the straw that is breaking your video cards back.
My advise would be to upgrade to 2 4850's. should be able to get them for under $170 each.
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