I'd also disagree on the "spam button" idea...

Even with my prot paladin, I ended up being a "clicker" for seals/judgements and only really put "Holy Shield" on my spam button.

On my shammies, I have CTRL+1 through CTRL+6 set for defensive totems (water, earth, air, tremor, groundings, totemic recall, poison/disease). I also have SHIFT+2 through SHIFT+6 set to heals (quick emergency heals, healing wave, lesser healing wave, chain heal specific target, AoE heal - chain heal off "buddy", GotN). Lastly, I have 1-7 (plus SHIFT+1) for my DPS spells (lightning bolt, PvP damage shocks -- FS on rotation, PvE damage shocks/interrupt -- all ES, chain lightning, searing totem, magma totem, fire nova totem, flame shock -- mostly for stealthers, purge).

And that was just my leveling bindings, and doesn't count the bindings for buffs/mounting that I put on my xkeys.

Take a look at how I end up being a "tank clicker" here: http://www.gamevee.com/viewVideo/Wor...iboxing/309646


I loathe excessive use of castsequences or even castrandom. They're useful in certain places, but IMO the spirit of multiboxing IS the multi-tasking. The only real times I use /castsequence is something along the lines of:
/castsequence reset=12/target Curse of Agony, null
(prevents me from having to CoA twice -- not only a waste of mana, but CoA is backloaded -- in case one char was incapacitated or barely out-of-range and needed to recast)

/castrandom is completely unreliable for tanking anything that can get you crit or crushed. The only thing I /castrandom are my DPS trinkets.

Removing that level of control from your characters makes you less likely to be able to recover from new, unprecedented situations. When someone gets the jump on me in a way I haven't anticipated, I still have a high chance of success because I, too, can be dynamic about my spell choices and actions.