Instance: Culling of Stratholme
Box: 4x elemental shaman + individual druid tank
Gear level: <pre-heroic blues/70 epics, Druid tank in mixed wotlk blues
Difficulty: Normal, very doable. First time run, not done on normal, wiped 6/7 times on the dragonkin part to come up with a tactic that worked but otherwise flawless.
Guide:
first Trash, 5 so called waves of undead elites. I killed the ghouls first, the ghoulds did a lot of dps on the tank. The druid also always entangled the big ones if they were present. This helped alot too. But mobs are quickly burnt down. Kill one target asap, pref a ghoul and the rest should be easy. On the larger pack with non elite casters, drop groundings and mix in chain lightnings, they die rapidly.

Meathook:
Well, he's basicly tank and spank. Groundings and cure disease totem or dispells are prolly needed here, or will make things a lot easier. Bit overall he doesn't do much dps. Could easily grind him down.

<More of the same trash>

Salramm the Fleshcrafter
He too is seriously easy, compared to the trash. Grounding totems seemed to help, killing his ghouls is a must too, since the corpse explosion for 6k otherwise, but my druid picked them up, I just mixed in chain lightnings, was enough to kill them. Little damage on the tank. Easy fight. Note this was our first ever CoS, Straight to heroic, we slacked a bit figuring out what to do and didn't make timed. Altho I'm positive Ill have that next go too.

Now comes the hard part!

Drake Trash making druid mash!

Ok, you done the first two bosses and you have to meet Arthas at a house further up, when you talk to him there, you will get a total of 4 spawns with drakes and then a boss. There is little time between the trash, you will get some time to rest before the boss however. The first pack of trash is easy. I just tend to kill the caster mob, then the hunter. Always leave those other warrior like mobs for last, they can put up a shield and really, you dont want to waste a second of dps on these trash. So kill hunters and the casters first.
Well, the second is already troublesome. Two casters, one hunter, one warrior drake. Now, On this pack, the druid picks up the two casters whilest I have grounding totems put down and I nuke the hunter down quickly. He will taunt the hunter when one of my chars gets hit. you might want to drop an earth elemental or two before the drakes spawn if you have trouble here. Maybe pop a bloodlust, but I suggest you keep them till later.
The third pack of dragonkin is somewhat easier. Arthas walks through a hallway and you get ambushed by four drakes, two on either side. What we did is wait a lil bit back where the two drakes behind spawn. We massacred those two asap and then quickly went to the two arthas was tanking. This is however risky, Arthas cant take much of a beating. But I found that tanking three for the druid tank with me was too much.
The fourth spawn is imo the hardest. If you get to this point, you are likely to be low on mana, likely have to down a mana pot. But the spawns come from forward. I did this pack by nuking one caster dragonkin and a hunter next, while I was on the second target I dropped two earth elementals just in case.

Chrono-Lord Epoch
This boss is the hardest boss in the instance. In my opinion however, if you could do the dragonkins leading up to it, you can do him too. He seems to sometimes go berserk on the tank, or he starts whirlwinding and moving towards you. Basicly stay at max range. keep the tank topped as much as possible but keep dps up, its a fight that eats mana, so dont want it to last too long.

Trash to last boss. Well, this is an easy part, if you keep your speed up. Have your tank pull elite after while you massacer stuff, halfway through arthas allows you a moments rest. Make sure you kill all ghouls and drink up whenever possible. But try to keep a pace and it will be easy. Obviously dont go too fast as you dont want to be overwhelmed either. Rotating thunderstorms seems a good way to deal with all the zombies.

Mal'Ganis
Is a PUSH over. I expected a hard fight, but what I got was free loot. I caught on quickly, you need to spread out for this boss, your characters about 10-15 yards apart. He doesn't do much damage so healing shouldn't be a problem. As long as you are spread. Grounding totems are essential. But basicly, you cant go wrong here. Very easy boss. Easiest in the entire instance. If you don't have grounding totems, whenever the boss changes his target, expect7-8k shadow damage on that target after 3 seconds. Because it is so predictable, you should be able to do this fine with a group without shamans too.