I just wrote this for my xkeys like no shit 1 minute ago, cus I was thinkign of it lol.

#showtooltip Super Mana Potion
/use [modifier:shift]
/use [modifier:ctrl]
/use [modifier:alt]
/use [modifier:ctrl,modifier:alt]
/use [nomod]

put the characters you want to use with a MOD, and then leave the rest blank. Put the same macro to all of them but change which modifier that they use the trinket on.
If you dont have an xkeys then you could ues a keymap in keyclone, binding 4 different keys though to one of the modifiers + different key.