Yeah, x-perl + dk = no runes. I use ICE HUD as well as x-perl and it does display runes, meh.

If you want a free alternative to kavoom, get synergy or multibox. Both are really good, I prefer synergy, but use multibox on occasion for mouse broadcasting.

synergy makes the clicking soooo much easier.....

A few suggestions for you, after reading your misc. (I am also 5x pc 5x monitor).. Tho, as a disclaimer, I haven't actually level'd my 70's to 71 yet, or visited the new continent. I'm procrastinating for some strange reason).

I assume you have (didn't explicity say) some method to broadcast keys, since you have NOPs....
Why don't you try to exploint synergy for things that you commonly do? I bought an x-keys pro but havent had a reason to use it yet. (I am a bad bad boy =x) I try to keep everything on the keyboard, sofar successfully. The pally + shammys are threatening to spillover tho. Hmm. I can see where with a mixed team you'd have alot more keys than me, but still, a certain amount of synergy can be obtained...
For instance:

theres a 'tank' key that cycles through agro abilitys for the tank (pally)

a 'single target' dps key (currently just /cast LB, but if i ever level in wrath im gonna turn it into a /castsequence for the shammies. for hunters it /castrandom's melee and ranged abilities and i spam the hell out of it along with disabling sfx, single target castsequence for dk's).

A multi target key...( Multi-shot on hunters, CL on shammy/prot shield talent for pally/castsequence ending in pest and blood boil for dks...)

I use ctrl 1 through ctrl = for various utilities that don't get hit 'every fight'. (Eg, totems, raise dead, my panic button that has everyone heal or fd or whatever ) and alt 1 through 5 for healing, so can pretty much do everything i need to without moving my left hand. right hand floats around for mouse targeting/turning slaves/doing all the other weirdo keyblinds that arnt part of the number keys. lol.

There are some serious advantages to having controls on the x-keys....(i used it extensively in EQ at first)...But its only really beneficial if you are partial to playing characters individually... (Wonder if it would be possible to have an addon that (out of combat, of course) switches between a solo and slave macro/keybind configuration. It'd be kinda cool to have a 'battleground' config too for us slackers on PVE servers. ) For me, my left hand literally hovers over my keys, and couldnt stand moving it a few inches to the x-keys regularly. synergy is key, lord knows we have enough keybinds as is..lol.

just my 2cents, take it with a grain of salt =0. I havent really changed anything since wrath. (other than build macro's for my new DK team)

With regards to addons, egads, im an addict:
Jamba is god. I use dominos, but I really should dive into macaroon, but im lazy.... Hmm, I use a ton of addons, but most don't pertain to multiboxing per sey. (I have this obsession with useless info...)
Smartbuff is pure gold, I couldnt play without it.
I keep switching between smartmount and livestock for a 'mount' addon. (Chiefly because smartmount broke with 3.0.2...(got fixed later but not before i swithced to livestock) and then I went back to it, but dk mounts don't work with it, so I'm back to livestock. meh. Smartmount is vastly easier to configure. (yes, im lazy and want to minimize macro's.)
Minipet because random vanitypets are just neat now that you can carry around 40 pets. LOL.
x-perl, and ice hud. (not really related to each other. I keep threatning to uninstall ice-hud but talking myself out of it).
altoholic(can search yer alts inventory, was useful during hallowween when iw as trying to collect all wands and trick or treating with alts)
Hmm, aloft is pretty useful nameplate addon.
Acheron is useful whenever you die horribly and are not quite sure why. This might only happen to me, tho. I installed it cause Mogor kept eating my pally, hehe.
Baggins is god. (well, get a bag mod, whatever you prefer. But baggins is nice. Ties in with outfitter to auto stick my outfits in a seperate category. really great for finding stuff in 5x inventories)
IHML - useful for daileys (so kinda useless right now, until new daileys.) Tho its configurable, so if you find yourself needing macro's in instances (eg, i made one for the HH fight to /target head of the horseman
Buffet - cause who has time to manage food. Also combines food and potion buttons, econmy of space FTW
bugsack - cause UI errors on alts are a PITA....
clique - for 'oh sh*t' unit frame casting on pally. (hand of protection/etc) and unit frame healing.
lightheaded - very nice for questing.
tourguide - sometimes i am efficient and follow its guides. mostly I jsut make things up. Should make a multiboxer tourguide guide some day. meh.
omen (threat yay),
advanced tradeskill window - nice for tradeskills. well, except enchanting.
talented - I love it on every char except my hunters. the new pet talent window doesnt jive very well with talented...
sct - scrolling combat text, very nice for main char at least.
outfitter - equipment switching, automation for mounted/unmounted sort of stuff
postal - kinda like mail-ct mod. useful if you auction stuff or get lotsa stuff in the mail
mrplow - item stack managment. very necessary if you use something like baggins and thus never look at yer inventory
quartz - very nice casting bar addon, i like that it highlights your latency in red so you can 'guess' when its safe to move yer char while casting.
lootfilter - semi broken since 3.0.2 (auto open clams/etc broken now), but still useful for 'select all greys and delete them' so i keep it installed.
spamsenty - blocks spam, yay! Sometimes it thinks things that are not spam, are, though. so check it when it says 'do yo want to report soandso.

all the standard (useless?) info addons...cartog, questhelper, atlasloot, atlas, recount, auctioneer, auditor2 (money tracking), auldlangsyne, gatherer, questguru (quest history), drdamage(theorycrafting on tooltips), fubar (equivalent to titan panel, looots of questionably useful info), historian, mobinfo2, prat 3.0(name color coding in chat, other cool but nonessential chat things), snapshot (gear history at ding) tradejunkie,

Hmm. apparantly my posts are somwhat like my desk...disorderly, lol.