2) Multiple instances of WoW in multiple folders allows settings to be set correctly and permanently rather than having to do setting changes each and every time.
3) Turning off shadows fixed the problem. I'm able to maintain my multisampling and color-depth and still run 3 instances of WoW without any issues anywhere. I've decided to NOT to limit my FPS for the time being until I notice more slow downs with my current set-up.

Defragging also helps...

Thanks for your assistance, elseguno...I truly appreciate it!