The only key on my DNP is NumLock.

That's it.

If I want to chat, I hit my Pause key. Other then that, I use a lot of keybinds for play, and they're the same on all my toons.
I wouldn't want to not be able to use wasd, for my non-current main. Shift/Alt/Ctrl W, Shift/Alt/Ctrl A, Shift/Alt/Ctrl S, Shift/Alt/Ctrl D... are all keybound.

For questing, I've found it to be incredibly useful to be able to "/use Item Name" or to "/cast Astral Recall" without wasting a keybind on something simple like this.