im having the same problem, I really wanted my mouse clicks to register on my other machine to make looting and questing, stuff in general alot easier for me. I couldnt find much in the way of monitor size help. since my main screen is a 22" wide screen and my box is on a 19" CRT. I tried changing the resolution on the crt but the click never registered in the same spot, and after awhile I could see them registering at all.