I really haven't played with mine as much as I should have but I currently dont use any paging.

My setup is pretty basic with the main 8 buttons being 1-8. The 3 buttons at the bottom are 0,- and = and on the left its tab, 9 and something I havent used yet.

Instead of using the pages I just use mouse4 and 5 as shift and alt and use those modifiers for all my skills.

The top 4 main buttons are where most of my offensive skills are like lightning bolt, shocks, chain lightning, thunderstorm. The other 4 are for heals and totems.

Probably not the best setup but does the job. Not sure I can ever go back to keyboard though, might need to get a spare N52te just incase!