I did Hellfire on my 3x afflic locks before I got Seed ... and yes ... dude, it's great.

I didn't actually discover "HEY! I can put this all in one big evil destructive awesome macro!" until recently ... locks have their trinket + SoC macro, and on the same hotkey is the pally's Holy Shield - Consecrate - Hammer of the Righteous. Botanica goes down hard with this!