Currently to my knowledge its not possible to run 2 mulitboxed accounts on one computer for Lotro. I myself have wanted to do this. Issue has to do with Lotro as a background window and keyclone's ability to communicate with it. Only way it can be done currently and I am doing it, is 2 computers. Then it works fine.

It is possible however to get 2 lotro accounts to run at the same time on the same computer. I took the info I read and tested it myself and my system had no problem running it.