I'm not sure what you mean by hotstrings, but I play multiple toons with the same setup. I usually put most of my macros related to a particular team under the toon macros, but common macros like group accepts, trades, etc... I put under the global macros. I also use Bartender4 without character specific key bindings in order to have the same keybindings and layout. Where you put your spells is totally up to you.