Make sure you have the right profile button lit on the keyboard. (ie. M1, M2 or M3).

When you're sure that's done, change profiles back and forth and reinitialise the keyboard. Or press M2 then back to M1 again.

(They're the only things I can think of that I had problems with with my G15. Alternatively, adjust your keybinds/macro's to match the standard g15 set up and never worry your head over it. xD )