you need to read up on symlink and work out how to run WoW from 1 "real" copy and 4 symlinked copies, it reduces disk thrashing a LOT. I run 5 on a e6400 @ 2.2ghz with a 8800GT, and get 60fps in outlands on my main and 30-40 in shatt. I also use the macros to reduce my graphic settings on the alts, helps a lot.
Of course WOTLK is a lot more demanding, I'm going to upgrade to a new PC with quadcore, 4870, 8GB, and vista64 later this month.
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