Maximizer scales your windows so you need to make sure you set the resolution of each instance to the new native resolution. From what you describe I would imagine that the first instance is set to 800x600 but the rest are on 1024x768 or similar.
assuming you are running on a widescreen and a standard monitor with resolutions 1920x1020 and 1440x1020 (just guessing)
and that your 4 instances on your 2nd monitor are 2x2 then each needs to have a resolution of 720x510
in your WOW directory is a WTF directory with a text file called config.wtf
edit this and change the gxResolution "1024x800" (or whatever it is) to gxResolution "720x510"
I run my main at 1920x700 and 2 clones at 960x500 using maximiser and this technique
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