1. As noted above, you just have to do movement with your main that your following toons end up facing the mob. When a mob runs through my lead shammy to hit the one that crit, I back up with him, spamming my cast button, if I don't get cast bar going I keep backing until I've backed through the mob. Quartz is good for this, you get a fast visual indicator that they can cast.

2. I tend to pause keyclone and manually type in all my passwords just because it feels more in control. however on the main keyclone window (the small one) there are buttons labeled dnp and rr (do not pass and roundrobin), these are override buttons, you can use them to turn off the do not pass list, as keyclone explained to me, for example if you wanted to /wave at someone with all toons but had WASD on do not pass. You could override (turn off) the do not pass list with that to enter your password(s).

3. Falkor has done some good work on this, I think he has the closest to a true automation to date, read this thread. Automation of Quests (Including Slaves)

4. You can attack with main and have your slaves assist and attack with the same keypress, the key is to make the main attack with a special attack, not to start autoattacking. For example you set '2' on your main as hamstring on your warrior, who is either the focus of your slaves or is party1 (the leader). Then on your slaves you set a macro in the 2 slot for either /assist party1 and /cast lightning bolt on the second line or use the traditional /cast [target=focustarget, nodead, harm] [] lightning bolt verbiage. My grasp on the syntax isn't good but that's the gist of things. Then you can spam your 2 button. The reason not to have autoattack as the main's 2 button is he would stop autottacking with every 2nd spammed lightning bolt.

5. At low levels the difference between killing and questing isn't massive, it's big but you can make the argument. At higher levels questing turnin xp skyrockets and mob kill xp doesn't. Long term questing is the way, mixed in with some judicious instance boosting if you have the resources and interest in boosting. People have quested to 60 with RAF in ridiculous short times, the same has been done with boosting. Pure grinding outside instances gets left in the dust apparently.

The above are comments from a noob with minimal experience hands-on but a ton of time lurking and reading.