with RAF you can skip virtually all the collection quests, there is enough XP to never bother doing any of them.

That said, if your monitor is big enough (or buy a 2nd monitor, its worth it esp for only an extra $200-300 for a nice 22") with just dual boxing you can arrange the screens side by side, and get PowerToys for Windows XP from microsoft (google it). You can turn on an option in PowerToys (under mouse) so that any window that you mouseover becomes active, so it just becomes a matter of moving the mouse, right clicking, and moving back.

There are ways of zooming in and broadcasting clicks (with Octopus or Keyclone) so that you can kind of try and click once and both windows get it, but tbh I've never really had it work well.

I 5 box and use Octopus, have F1-F5 bound to my 5 toons and they are all window stacked on top of each other, one is on the side since hes a herbalist. I have ingame macros which /focus <person> bound to F1-F5, and my F key is bound to /follow focus which I spam a lot, and so the way I do collection quests is just rotate between my party and each collects/kills as many as they need while they are the leader of the group. It switches instantly screens since they are all stacked, I found using maximizer/PIP and arranging windows so I could see them all just lagged my gfx too much.