I'm not sure about targeting in script anymore. Well I'll jsut say targeting specific stuff. I'd give a once over the change list for the macros and scripts. I beleive that made a lot of stuff not able to be done in script anymore to off the one button smashers. One buttons with a script that thinks for them. I'll look into it a little bit see if I can confirm it. I haven't done much scripting for WoW though so I could be completely wrong on this. After thinknig more I really like the mouseover idea. I tested it and it's really easy.

[code:1]
Here's the mouseover focus...
/focus [target=mouseover]

and this sets your target to mouseover.
/target [target=mouseover]
[/code:1]

I'm sure you could do somthing with it more, but that's the basics for it. Like you said prioritizing and synching would be the issue.

So where you thinking ideas like that? or Other things as well? I can ramble on all day about some stuff...