I am happy to say the clicking the "2" button twice is now fixed! After the last poster said something about macro configuration I was thinking about this macro I found and was using:

/target focus
/follow
/assist
/stopcasting

I was hitting this as my "big button". So I took it out and simply used a /follow...then hit the "2" and it worked with one click, woot! I don't completely understand why, but there must have been something in this macro that was conflicting with the /assist macro I setup.

I have one more question...I know people are shocked. How do I set-up my Lightning Bolt macro on the alt so he keeps nuking till the mob is dead? Do I just remove /stopcasting if it's on there...or do I type in /cast Lightning Bolt multiple times? Thanks for your help!