There was a spat a while back between the owner/programmer of glider (bot program) and the owner/programmer of Innerspace. As far as I could tell from the glider forums to do with the code that at the time prevented WoW's Warden from detecting Innerspace, and the the Glider author wasn't prepared to license the code form Innerspace to stop his users getting banned.

I have no idea how the spat ended (and don't care much) but I do recall reading at the time that Innerspace users have been banned! Mainly as Blizzard state that the only reason to have Innerspace installed/running concurrently with WoW is to use illegal mods. Warden has in the past certainly detected Innerspace.

That all said how the owners of EQ2 feel about it I have no idea. But if Blizzard consider it a threat to their revenue then I could see it being moderated against by other MMO companies.