I have a friend who has the exact system I do and he tries to run 5 clients & keyclone. It will run on occasion but the difference between my system and his is that he runs KDE and I run GNOME. He has intermittent lockups which affect the entire system when running Wow. Even when he runs only one client this happens. So, what I gather from this is that KDE not a good mix with Wow. I use Nvidia/Gnome. Of course I will also say that if you an ATI video card don't bother. It's really more work than it's worth. That doesn't mean it can't work. I got it to work on my Compaq laptop with an ATI 200M. But it could not be run on display :0 it had to be on display :1 or up. In case you want to know how to do that it's actually quite simple.

For ATI:
Boot, do not log into linux.
Press <ctrl><alt>+F2 (or F3-F6) then log in.
Type "xinit -- :2 (this will start a terminal session on <ctrl><alt>+F9)
Press <ctrl><alt>+F9
Then move the cursor to the little terminal window and change to the Wow folder.
Type wine wow.exe (-opengl if you don't have that set already in your Config.WTF)

I don't remember all the reasons ATI will not properly do OpenGL on display :0 but anyway this works.

Also I've noticed (with my system) that if you make sure you have "[X]Use Hardware" checked in the sound section of Wow that this does improve performance.