I have not personally tried out Hotkeynet but from what some say its a great program though it takes a bit to setup if you have never dealt with a program just like it.

I use Octopus, now as far as Vista is concerned you might have the whole admin thing going there, quiet a few programs have issues on Vista due to the admin restrictions. Now to solve this you will need to make sure you have admin rights, this might mean you will go in as admin or set up and input the admin password I do not have vista but everytime I see something with vista and some of the programs they talk about here it is due to admin issues.

I hope this is not the case since I will be setting one up this weekend on a vista machine for my friend, he is not very computer literate so got to help him out since he has 2 accounts and wants to multibox.