G'evening Timpyroz and welcome to the forums!

yes, using keyclone you can toggle mouse-click-passing on and off using a hotkey you specify.

for interacting with the quest givers, you would drive up on your main with your alt(s) on /follow. the camera on all your characters would normally be roughly the same... all the way out being most preferred. drive up with the QG on one side, then toggle the mouse-click-pass on, hear the 'up' tone, then click... don't move your mouse and watch as it jumps from screen to screen clicking in the appropriate spot. then hit the hotkey and toggle mouse-click-passing off.

i use this fairly regularly while 5 boxing.

if you have any other questions, please feel free to drop me a note.

have a great night and welcome to the addiction,

Rob (keyclone developer)