G'morning Camelot and welcome to the forums!

for future reference, sending me a PM instead of posting these types of questions to the public forum would be better. there is no one else that is really going to answer...

anyhow, on to your questions:

yes, you can move or resize the override overlay (the "mute" box). to resize, grab the border.. to move, left click and drag the center of the box.

i made it so you could 'tweak' existing commands to create a new command by simply changing the name. this makes setting up 5 commands fairly trivial. there is no real renaming capability... you'd have to select it in the list and hit 'del' to remove it

regions locking up? do you mean the wow is frozen? that's a problem, as wow should not be locking up on you. if that is not what you mean, please supply more info

the freeze-on-exit is a known bug that happens if you use the X in the upper right when exiting. instead, right-click the tool tray and exit that way until the next version is released.

as for layouts... you can create any layout you want. the ones on the layout pages are examples and are by no means a comprehensive list of possibilities

as for what the various fields are for, i have posted the information numerous times. the fields are fairly self explanatory:

as for what 'game resolution' does... it is the resolution you are telling wow to render. it is best to put in the size of your largest region, and all your smaller regions should have the same width : height ratio. for more information on exactly what wow does with this info, ask blizzard

and btw... 2G is barely enough to play 5 wows... and definitely not enough if you load up on addons