Glamour,

My setup is very similar to yours, except for the vid card - I only have an 8800GT 512. However, I do have 2 separate Hard Drives, the main being a Raptor (quite fast!).

I have 2 monitors, so that's where you and I will differ most. I have my main/brain on 1 of my monitors, settings almost maxed. I have the 4 alts on the 2nd monitor through maximizer, with all minimal settings and few addons.

Main runs out of it's own WoW folder on the Raptor. #2 & #3 run out of their own folder on the Raptor, copy/paste of the main WoW folder minus addons, of course. #3 & #4 run an exact copy of the #2 & #3 on my 2nd Hard Drive.

Everything runs beautifully and stays at 40-60fps on my main with each alt going from min 20 to max 40 (as set in Keyclone). Your machine will handle it all just fine. FYI, I have Vista, so dualview through nvidia control panel works great.