I guess you're talking about the multibox software?

I can't speak for the server side, but I'm quite happily running the client (receiver) on a VAIO VGN AR31S notebook running Vista.

Unfortunately, I can't think of anything immediately helpful to say other than reassuring you that it does indeed seem to work.

I'm running the regular version of Multibox (i.e. without any of the recent mods posted in various parts of the this forum), if that's any help whatsoever....