Vista64, Single NVidia 260, 8GB RAM.

I'm currently 3 boxing with 3 regions.

Display1 - To prevent the main window from overlapping the vista taskbar (major lag issues when it overlapps in the slightest), I've set the region to 2560x1550 with maximizer set to 1-1.

Display2 - Two regions, each set to 800x600 and maximizer 1-1.

I've never touched the UI scale option before, and am at work now so I can't try it. What does it do exactly and what should I set it to?

As an aside for others who might be reading this thread , focus follows mouse doesn't seem to work for me either. So I just used the Control Panel->Ease of Use->Focus follows mouse option instead which seems to work fine.