G'morning Matt,

you can set the game resolution for any region to any value you want.. just type it into the box just below the pip hotkey.

so, reset regions... create region... set the w,h to what you want... then click the game resolution and set it to the largest region you are going to define (this helps to insure the aspect ratio doesn't get out of whack)

have you checked out the layouts section? (link: http://solidice.com/keyclone/layouts/index.html )

how many wows are you trying to run on each display? what sizes are you selecting for the regions?