It's interesting that you don't find the Nostromo useful for complex movement, because that's exactly what I love so much about it. Of course I use it with a mouse as well, but I found the D-Pad to be incredibly useful for helping aid mouse movement. I also put forward, backward and strafe on it.

The breaks in the X-Keys are what makes it better than a standard keyboard for blind access I guess. But are the breaks good enough to compensate for having to move your hand?

You haven't used an X-Keys yet, right? I'm curious how those who have feel about it.