I use AHK and just want one screen in the center, and two on each side with the monitors in portrait mode. I am not as concerned about the frame rates of the other 4 windows, but I don't want them to be intolerable either. In the past I have used a 8800GTS and it was great when I had only one window visible, but if I tried to show more then two at a time at the same time, my FPS would drop pretty horrible. This was on a Q6600 CPU.

Thats why I was thinking 3 video cards, one for each monitor and the center one would only have to display a single wow window, with all the eye candy turned up.

Best buy has 42" 1080P LCD tvs for 800.00 right now, and I currently run a 37" as my monitor (also 1080P). I was thinking of picking up two of them to go on either side of my 37" in portrait mode.