If you can't understand the guides, which make things as simple as it gets for you, I don't understand what you expect us to do, we'll all just tell you the same thing as the guides say, Make X Macro, Bind it to Y Key, etc.

Work out what classes you'll be using, Work out what spells they use, work out which spells it'd be useful to use at the same times, and which ones it'd be best to use seperately and go from there. It takes people ages to setup Macros, you're not the only one who's finding it difficult. If you have any specific questions, feel free to ask here or on IRC.