2) 6GB of Ram, Quad Core Processor, 1 22" Monitor, Geforce 9800GX2 1gb Video card, is this enough to even run 4 instances of WoW? My thoughts are yes from what I've read, just wanted to make sure.
Without a problem for sure
3) Is running the instances in Windowed mode possible or do all have to be open at once, 1 Main window almost full screened with 2-3 windowed.
Its possible I run four in windowed mode scaled down and lined up nicely with the main window maxed
Also, should I be investing into a new keyboard with more keys for macros?
If you want, I use a standard laptop keyboard and thats more than enough for myself.