there isn't much information there to diagnose the issue.

are you running on vista? did you 'run as' admin by right-clicking on keyclone and selecting 'run as' admin?

what are you using for targeting?
are you clicking with the mouse?
what macros do you have set up?

test keyclone to see if keys are passing by jumping... hit the space bar and all your characters should jump

talk to you soon,

Rob