Although strange at first, I found that unbinding ASD and using only QWE for movement (left strafe, forward, and right strafe) helps alot in both PvP and PvE. I can't think of any time that anyone should actually be backpedalling or keyboard turning on the main characters unless they are controlling all the clones at once (and in that case I use the arrow keys below the home/end/delete/pgup/pgdown part of the keyboard). This has also freed up 6 more hotkeys.

Anyone else use a similar system? Or is there any actual reason to keep the backpedalling button bound? The only reason I can think of is if you are controlling a tanking character, where facing your back to the mobs will probably result in death and/or daze, but if you are using only caster toons is it fine?