( I am using a single screen Pip setup)
I set the decursive boxes as big as they could go so I don't have to struggle to see if someone is debuffed. Then I bound my pally's purify, mage's remove curse, Priest's dispel, and Shammy's posion/disease totems to my F2 key. I set the priest and Mage's macro to assist <name>. I just watch the boxes and if I see someone debuffed I just target them and hit f2. It may not be the most mana efficient but it has worked for me so far I hoe this helps.