You can download the addon "multiboxer" or some others that will automate tasks like accepting group, accepting shared quests etc. I usually grab the quest on my "main" and share it. The slaves automatically accept unless it is a chain or something that requires each one to get it. The PiP thing seems to work great for me, or if I feel like straining the eyes i just mouse over to the other monitor. I have octopus setup to automatically change the mouse focus to the current window.