I too was struggling with low fps while trying to box my 4 accounts. Here is the long story of my setup and the different things I tried to boost FPS.

Vista ultimate 64-bit
Q6600 @ 2.4
8gb ram (800mhz)
500gb 7200rpm 32mb cache HD
BFG 8800 gtx 768mb
Running main on 22” LCD ( 1680*1050 )
Running bots on 17” LCD ( 1024*768 )
I run 4 wow folders (wow1, wow2…) with symbolic links on the data and cache folders from wow1. This allows me to run different mods on each account and set different video settings on all accounts. My main will run with fully loaded settings apart from the terrain view distance that I have that set to half. Bots run with everything set to the lowest.

The mods I use are as follows:
Main:
Bongo bars
Xperl unit frames
Questhelper
Titanbar
Whisper Relay
Cartographer

Bots:
Bongo bars
Xperl unit frames
Questhelper

Running the symbolic links may have given me a few extra frames note sure as I was not taking notes. However the load times were greatly reduced.

I run core affinity set to the following.
Core 0 – OS only
Core1 – Main
Core 2 - Bots 2 and 3
Core 3 - Bots 4 (and some day 5)

Running an account across all four cores had a negative impact on my performance. Doubling up the bots on single cores corrected it. My single core that runs two accounts right now will fluctuate from 70-100% for that single core. Now that is not total system usage just what is registering from the single core graph. For me this seems high but I have not figured out how to reduce it. I have a lemon of a q6600 and have been unable to OC it very high. I am testing running at 2.6ghz right now and can see that it buys me a few fps. I just have to see how stable it will be and go up from there.


Now I am in no way proficient with configuring octopus so those with more experience please do chime in.

Running main full screen on the 22” and bots use ¾ of the 17” I was getting poor frame rates. I had capped my bots to 15fps and my main at 60fps. Yet I was only able to get 20-30 fps. In Shatt I would go into the single digits.

Now when I say I was running the main at full screen it really was not. I play in windowed mode so that I can move my mouse from one screen to the next to perform manual tasks on the bots. Choosing loot, quests dialogues ect. In windowed mode the start menu and taskbar would always show as the option in windows was always on top. This bothered me as it covered part of my wow screen. I modified the maximizer so that the main screen was compressed a tiny bit to accommodate for the task bar and start menu. I thought that it was unavoidable as I did not really want to turn of the taskbar always on top option off.

However after some experimenting I found that if I set the screen resolution to the full 1680*1050 of the monitor and turn off the always on top option I gained a significant performance increase. My FPS went up to 30-60fps on my main. In shatt my FPS can go into the 30s. I guess rendering the game plus the taskbar was too much for it.

Anyway I thought I would add my experiences thus far to this thread, as some of the fixes seemed quite obscure to me.

I am at work trying to write this on the sly. Sorry for typos and such.
Oh and sorry for the wall of text.