I tried the three monitor route but i found two to be enough for 10x with full screen stacked and 1 dxnothing.
You may try dx9 mode over the default dx11 mode to improve performance. I saw a large gain for all windows when i switched to it.
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Woudl you mind putting a ss of your setup? perhaps im trying to put too much information on my dxnothing, but im having trouble trying to fit all 9 extra toons on 1 dxnothing. so ive been using 2 dxns on 2 other monitors left and right of the center stacked and using monitor 4 and 5 for scouts.
I linked a single dxnothing that has information from 11 different clients, with some room to spare. The trick may be for you to scale them down a little bit (as it was for me)
scaling might work, but i have bad eyes ( wonder why ) and i have trouble reading smaller text. but i might have to consider scaling haha.
had an incident where i jumped my scout into 1 system and my main into another thinking it was clear. the gate camp on the other side was happy to see me and i was really confused. haha