If it crashes when you try to IWT but have no target, that would definitely be a WoW bug to report, and it would explain to me why people would get it intermittently with ISBoxer, but not typically without.
Here's why...
The inherent delay in /assist, as diagrammed here from
http://isboxer.com/wiki/Game_features#Assist
Attachment 711
.. will increase the odds that your slave windows will randomly crash due to attempting to assist. You would get this crash intermittently on slaves when you select a mob and immediately press IWT. The longer you have your target before pressing IWT, the safer it would be.