Originally Posted by Ellay
Going to chime in :)
When making setups keep it simple!! The more variations of classes thrown in the harder it is to manage. My angle and I would venture the same as Xzin is to combine a healthy dose of PvP and PvE and make your setup compatible with both. If you lean for just PvE a higher mixture of classes is doable since all fights are predictable and there is time alloted for setting up strats.
For PvP reactions need to be intuitive and on the fly, thus having a core of the same class enables this to be much easier. The main issue involves loss of control of your characters, I.E fear / and aoe fear. Make sure your setups have a counter to this method. All pvp trinkets remove it now which is great.