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I've not really used Clickbars much, as I am more of a Keybind clicker than a Mouse clicker.
My understanding of Clickbars (not 100% on this, as I don't use them much)...
You pick the graphic you want for each button, scaling and positioning it.
They can be placed in a grid, so many buttons across and so many deep; you could go a 1x1 grid for a lone button.
You can place multiple grids.
Each Clickbar should be set Target: Current Window.
Clicking a clickbar is the same thing as running a mapped key.
The mapped key can do whatever, and that is what really determines the target.
The mapped key can have multiple steps.
And can load/unload a clickbar (plus its image) as a step in a mapped key.
*Edit*
Some Clickbar threads: http://www.dual-boxing.com/showthread.php?t=33614 or http://isboxer.com/forum/viewtopic.php?f=21&t=251
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You will not want your healer healing every time you spam "1" you'll be oom in no time