I'm not aware of any step-by-step guides with pictures for ISboxer but Lax has a youtube video that goes through a simple setup. here is the link: http://www.youtube.com/watch?v=xoZG6b9HjnM
Also, the quick start guide is pretty simple. http://www.isboxer.com/index.php/com...ck-start-guide
Once you get up and going with a basic setup, Ualaa's guide to ISboxer is a must read.
If you are having trouble with a specific issue, I would also check out the ISboxer's IRC channel. More often than not there are people in there that can help.
I've only been using ISboxer for a few weeks so I'm still learning and customizing things for the way I like to play but I'm very happy with it. It is such a feature rich program that you just have to put in some time to understand how it works. My boxing consists of PvE with mixed groups and the healing options with repeater regions and click maps are what sold me on ISboxer.
Good luck!