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There is an issue with all 3870 and 4870 ATI Cards, driver independent: If you run with 2 monitors and you rotate your main display by 90 degrees in any direction, your system will start stuttering once you move any 'graphics' window into another display. I confirmed this behavior with EQ2 & Civilization IV. We didn't have a copy of WoW around, so we didn't try it on our regression box... With a pair of 9800 GTX nVidia cards, we did not see this failure. ATI is aware of the issue, no eta for resolution.
Otherwise, I run a pair of 4870's in MultiMon mode and run 6 instance EQ2 on it, works like a champ... So Wow should eat it up. g'luck
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I run the 4870 with a 24" and a 20" (for the four slaves). I run my main screen at full settings and the slaves set a bit lower. I've yet to experience any issues and it runs as smooth as butter.
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no you wont have a problem.
4gb mem goes without saying
dalaran will probably still kill you but rest should be fine.