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You can't use modifiers for combining spells underneath one button because these modifiers are used already (thus you get less buttons available that you can use for other class types in your group).
- not entirely true, you can use modifiers even with the normal ftl-setup by simply defininf another keybinding/keymap for the version with the modifier.
If you again used the only leaderless/targetless setup i mentioned you can een use keybindings like you would do now
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Your group is not flexible anymore, you can't just put any character in your team and have a go with that same team, because the names of your party members are hardcoded in your macros.
True, but this the only thing you have to change is the assist-macro, and if you use this with the /click.. like i mentioned before its only one macro you need to change. Additionaly also in a normal focus-based approach you need to change at least one macro, if you are not using party1 and so on...
..and if you are using party1, what do you do in groups, where you are not the groupleader, or even not all in one group?