Action bars become non interactive after an hour of game play.

After about an hour of playing i noticed that 2 or 3 of my characters arent attacking or using the loot a rang. Basically everything that is on the action bars is inaccessible, i cant click the hot key, i cant click on the action bar, i cant use the spell from the spell book. Only the follow and assist commands work. Exporting from isboxer tool kit or re launching the team from inner space does nothing to fix the problem. the only way to "fix" it, is to log out to the character select and then log back in. then they all attack for about 1 or 2 hours and then random slots lose the ability to attack using any method.

i dont have any action bar overlays, i have the stock blizzard interface, i only use Isboxer, Zygor, Dugi questing essentials, and Recount. I have tried uninstalling everything but the Isboxer. still the same problem. I deleted the WTF, Cache, and Interface folders, I did a scan and repair in the battle net launcher, i re installed wow and isboxer. im not able to even click on the hearth stones in the main back pack, or click on the mounts in the mount menu, when this problem occurs so the toons are just basically on follow.

This happens randomly to one or two of my characters aswell, around 2 hours intervalls between each time. This only happen when i "afk farm". Nothing works, can run around and jump, but nothing else. Have to relog the toon. I thought it was some blizzard anti botting mechanic. Its not that bothersome luckily.

I have had this happen before as well but always just setting focus to the window fixes things, I do not have to log out.

Its always during certain situations where I am spamming everything. I am thinking like Wowbox40 just an antibot thing from blizzard, if it is then slowing down how often you spam your dps button or how many keystrokes are sent to each window every time would fix it.

As a side note, Recount uses a lot of resources and you might try Skada or similar. This is really old but:
https://us.battle.net/forums/en/wow/topic/20748725094

appreciate the input, what you say makes since to me. especially with how ive set the characters up. i have pro config buttons that have 5 or 6 steps and send a single key per step, to in game cast sequence macros/trinkets/racial abilities. very spammy.

I presume /console reloadui does nothing to help?

No it doesnt do anything. Have to log out and in again.

i have this exact same issue every night at least 4-5 times and it drives me absolutely crazy :\ i have found no other way to fix it other than logging out and back in as well

When does that happen ? Are you standing still and afk farming mobs or doing other stuff like world quests etc ? If you are afk farming even tho you’re pressing the buttons killing mobs etc your characters will go AFK status after I think 15 or 30 min, and then you can get issue you are describing. What worked for me in the past was simply just jump with all the toons every 5-10 min to avoid that.

hmm yea i am doing a stand still farm, i'll try jumping to keep them active

I have them all jump one time around every xx keypress, its in my re-keymap. That doesnt prevent the hotbars from locking up. Though they never go afk and jumping sometime fixes the looting (it can hang up sometimes). All my toons are only using instant spells to attack mobs. Its only 1 or max 2 of all my toons that gets affected.

Used same method for months. Getting the odd action bar lock started to happen very recently. And oddly enough only on a couple toons at most, when it does.