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It apparently hasn't been released just yet, but over in Japan the Elecom Dux (specifically the M-DUX70BK) looks fairly interesting.
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http://kotaku.com/a-gaming-mouse-des...ers-1744581316
http://www.4gamer.net/games/325/G032556/20151124029/
http://www.elecom.co.jp/news/201511/game_dux/
Its designed for MMOs and two boxing! lol
Where do you hold it?
Yeah no kidding.
I am not a big fan of buttons on mice. Ever since I could I've assigned fire buttons to the keyboard in any FPS I play. Just because pressing buttons on the mouse aggravates the cursor precision.
When it comes to input peripherals less is more IMO.
Oh I like extra buttons, just clear of the thumb and middle finger "grasp" areas. I have one of the steelseries wow mice and I use the extra buttons regularly. Especially for things like isboxer Next character swaps or similar.